Sabatini Lab News & Happenings....
2017

October

Dr. Jason Cantor is awarded a Margaret and Herman Sokol Postdoctoral Award

Publication: mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient

Publication: Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability

Publication: Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites

September

Audiohelicase, the Postcast of Whitehead Institute: David Sabatini

August

Publication: The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway

July

Dr. Maria Mihaylova, Ph.D. receives NIH K99/R00 Pathway to Independence Award

Dr. Sabatini is awarded the 2017 Dickson Prize

April

Publication: Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase

March

Publication: KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.

Publication: mTOR Signaling in Growth, Metabolism, and Disease

February

Publication: Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras

Dr. Maria Mihaylova, Ph.D., receives a Koch Institute Ludwig Postdoctoral Fellowship Award

January

Two Sabatini lab papers are chosen as part of Science Signaling’s Breakthroughs of 2016

2016

August

Press Release: Novel method enables absolute quantification of mitochondrial metabolites

Publication: Mechanism of arginine sensing by CASTOR1 upstream of mTORC1

July

Publication: Cell biology: The TORC1 pathway to protein destruction

Dr. Naama Kanarek, Ph.D., receives AACR Fellowship in Lymphoma Research

Dr. William C. Comb, Ph.D., receives NIH K99/R00 Pathway to Independence Award

June

Publication: Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer

Sabatini Lab receives Addgene Blue Flame Award

Publication: Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

May

Rita Allen Foundation: David Sabatini: Fueling Cell Growth

Whitehead Members Hidde Ploegh and David M. Sabatini Elected to National Academy of Sciences

National Academy of Sciences elects four MIT professors - David M. Sabatini tini

ASBMB Today: Lively lysosomes The organelles aren’t just trash cans. As researchers now appreciate, lysosomes do much more for the cell’s well-being

April

Publication: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

March

Special Issue Feature - The Scientist: A Different Way of Doing Things Cancer cells exhibit altered metabolic processes that may serve as promising targets for new therapies

Press Release: Scientists identify sensor that modulates key metabolic pathway

Press Release: High-fat diet linked to intestinal stem cell changes, increased risk for cancer

Tim Wang receives prestigious 2016 Harold M. Weintraub Graduate Student Award

February

Dr. Jason Cantor receives Koch Ludwig Postdoctoral Fellowship

January

Publication: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma

Publication: MERAV: a tool for comparing gene expression across human tissues and cell types

Publication: Sestrin2 is a leucine sensor for the mTORC1 pathway

2015

December

Scientists identify mTOR pathway mutations in follicular lymphoma

November

Publication: Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

The Altantic: The New Gene-Editing Technique That Reveals Cancer’s Weaknesses

Maclean's: Researchers herald a game-changer in cancer treatment

Cell: No Other Choice

October

Press Release: Scientists discover essential amino acid sensor in key growth-regulating metabolic pathway

Insights/Perspectives: Membrane traffic en route to cancer

September

Press Release: New Role for an old protein : Cancer Causer

Tim Wang, MIT Graduate Research Assistant, receives Abraham J. Siegel Fellowship at Whitehead Institute Annual Scientific Retreat

Shuyu Wang, MIT Graduate Research Assistant, receives MIT ODGE Fellowship

August

Dr. Sabatini recipient of the 2015 Glenn/AFAR Breakthroughs in Gerontology Award

Publication: Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1

July

Press Release: Amino acid shortage curbs proliferation in cells with mitochondrial dysfunction

June

Sabatini Lab holds first scientific lab retreat in Savannah, GA

May

Dr. Andrew Mullen receives 2015 Hope Funds for Cancer Research Fellowship

April

Medical News Today: Discovery of brain cancer cell weakness may improve treatment

Publication: SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

Publication: Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

March

Publication: Nutrient-Sensing Mechanisms across Evolution

Publication: Indentification of 6-phophofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening

Dr. David Sabatini named the Alexander M. Cruickshank Lecturer at the Gordon Research Conference on Lysosomal Diseases at Hotel Galvez in Galveston, TX on March 15-20, 2015

Dr. Ellen Edenberg receives 2015 Helen Hay Whitney Fellowship

February

Publication: Nutrient-sensing mechanisms and pathways

Publication: Metabolism. Lysomal amino acid transporter SL38A9 signals arginine sufficiency to mTORC1

January

Dr. Kivanc Birsoy receives NIH Research Scholar Development Award (K22)

Press Release: Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

Press Release: Systematic identification of signaling pathways with potential to confer anticancer drug resistance

2014

December

Liron Bar-Peled, Sabatini Alumni: Research earns top prize for young scientist

October

Thomson Reuters recognizes Dr. David Sabatini in the 2014 World's Most Influential Scientific Minds Report: Top 1% of Highly Cited Researchers

September

Press Release: New Protein Players Found in Key Disease Related Metabolic Pathway

Dr. Kivanc Birsoy wins Margaret and Herman Sokol Post-doctoral Award, Whitehead Institute

August

Publication: Dihydropyrimidine Accumulation Is Required for the Epithelial- Mesenchymal Transition

Dr. Monther Abu Remaileh receives EMBO Fellowship

July

Publication: Depletion of RICTOR, an essential protein component of mTORC2, decreases male lifespan

Dr. Kuang Shen receives Life Science Research Foundation Fellowship

Dr. David Sabatini receives the Colin Thomson Memorial Medal, Beatson Institute, Glasgow, Scotland

March

Fox News Interview: Researchers find new drug target for treating mitochondrial disease

Press Release: Scientists find potential target for treating mitochondrial disorders

National Academy of Sciences honors David Sabatini

Press Release: How diabetes drugs may work against cancer

January

Dr. Yoav Shaul, Ph.D. receives MIT Ludwig Fund Fellowship Award

2013
December

Press Release: Speeding up gene discovery: New gene-editing system enables large-scale studies of gene function.

November

Press Release: Gene responsible for hereditary cancer syndrome found to disrupt critical growth-regulating pathway

September

Dr. Omer Yilmaz, M.D., Ph.D. receives NIH K99/R00 Pathway to Independence Award

Walter Chen, Harvard MD/PhD Student & Sabatini Research Assistant receives NRSA Fellowship

Zhi Tsun, Harvard MD/PhD Student & Sabatini Research Assistant receives NRSA Fellowship

July

Dr. Kivanc Birsoy receives Special Fellow Award from the Leukemia & Lymphoma Society

Dr. William Comb receives the American Cancer Society - Ellison Medical Foundation Fellowship

Dr. Elizaveta Freinkman receives the Hope Funds for Cancer Research Fellowship

June

An Interview with David Sabatini  - Trends in Pharmacological Sciences

Dr. Alejo Efeyan receives the Charles A. Kings Trust Postdoctoral Fellowship

Dr. Brian Grabiner receives 2013 WI Spirit Award for the "Go-To Person."

May

Press Release: Protein complex in key cell-growth pathway could help predict response to cancer therapy

April

Sabatini family featured in HHMI Spring Bulletin

February

Dr. David Sabatini receives Feodor Lynen Award, 2013 Miami Winter Symposium, Nature

January

Dr. Maria Mihaylova named a Robert Black Fellow of the Damon Runyon Cancer Research Foundation

2012 December

Press Release: Cell surface transporters exploited for cancer drug delivery

Press Release: Nutrient-sensing enzymes key to starvation response and survival in newborn mammals

November

Dr. David Sabatini receives the Earl and Theresa Stadtman Scholar Award from ASBMB

Dr. Maria Mihaylova receives the Damon Runyon Fellowship Award

September

Dr. David Sabatini's Rapamycin Research Featured in the Boston Globe

Shuyu Wang, Harvard MD/PhD Student & Sabatini Research Assistant receives NRSA Fellowship

Dr. Michael Pacold, M.D., Ph.D., receives Department of Defense Breast Cancer Research Award

July

Dr. Michael Pacold, M.D., Ph.D, receives Damon Runyon Fellowship Award

Dr. Naama Kanarek receives the Weizmann Institute Women in Science Award

June

Dr. Naama Kanarek receives the EMBO Long-Term Fellowship Award

Lawrence Schweitzer, MIT Graduate Student & Sabatini Research Assistant, receives NRSA Fellowship

August

Dr. Richard Possemato receives NIH K99/R00 Pathway to Independence Award

Dr. Dudley Lamming receives NIH K99/R00 Pathway to Independence Award

March

Thermo Fisher Scientific Appoints David M. Sabatini to Scientific Advisory Board

Press Release: On the path to age-defying therapies

David Sabatini: Demystifying mTOR – The Scientist Magazine

2011
December

Dr. Jason Cantor receives the American Cancer Society Fellowship

September

Dr. Richard Possemato wins Margaret and Herman Sokol Post-doctoral Award, Whitehead Institute

July

Press Release: Key metabolic pathway implicated in intractable form of breast cancer

June
Press Release: Leucine Deprivation Proves Deadly to Malignant Melanoma Cells - Science News Daily

Press Release: A Tale of 2 Complexes: The mTOR Signaling Pathway in Cancer Development - OncLive

2010
July

Dr. Jacob Chudnovsky receives Small Project Discovery Research Grant from the American Brain Tumor Association

January

Tim Wang, MIT Graduate Student & Sabatini Research Assistant, receives NSF Graduate Fellowship

2009 January

Dr. David Sabatini receives Paul Marks Prize for Cancer Research

June

Dr. Kivanc Birsoy receives Jane Coffin Childs' Foundation Fellowship

December

Agios Pharmaceuticals Attracts Leading Cancer Metabolism Experts to Advisory Team - Appoints David M. Sabatini to Scientific Advisory Board

2008

December
Publication reporting use of a pooled RNAi library to identify genes essential in cancer cells

June
Publication reporting discovery of the Rag GTPases as key mediators of amino acid signaling to mTORC1

April
Dr. David Sabatini appointed as an HHMI Investigator

Pre-2008

March 2006
Publication describing the RNAi Consortium library

March 2005
Announcement of The RNAi Consortium (TRC)

February 2005
Publication reporting discovery of mTORC2 as the hydrophobic motif kinase of Akt/PKB

December 2003
Dr. David Sabatini named Charles Ross Scholar by MIT

July 2003
Dr. David Guertin wins a Damon Runyon Fellowship

April 2003
Publication Reporting Discovery of GbL, a New Component of the mTOR Signaling Complex

July 2002
Publication Describing Raptor, a Novel Protein that Interacts with mTOR

July 2002
Dr. David Sabatini Named One of the World's Top Young Innovators by Technology Review, MIT's Magazine of Innovation

October 2002
BioMedNet Story about Steve Bailey's Presentation at BioArrays Europe